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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK2
All Species:
18.79
Human Site:
S493
Identified Species:
34.44
UniProt:
Q7KZI7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7KZI7
NP_001034558.2
788
87911
S493
S
P
L
L
E
R
A
S
L
G
Q
A
S
I
Q
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
A500
V
Y
S
G
G
S
M
A
R
R
N
T
Y
V
C
Rhesus Macaque
Macaca mulatta
XP_001115591
788
87964
S493
S
P
L
L
E
R
A
S
L
G
Q
A
S
I
Q
Dog
Lupus familis
XP_540890
798
88683
S512
S
P
L
L
E
R
A
S
L
G
Q
A
S
I
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q05512
776
86287
S490
S
P
L
L
D
R
A
S
L
G
Q
A
S
I
Q
Rat
Rattus norvegicus
O08679
722
80853
T440
N
K
R
P
E
E
E
T
G
R
K
A
S
S
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
R499
F
P
G
G
G
M
T
R
R
N
T
Y
V
C
E
Chicken
Gallus gallus
Q9IA88
798
88848
S494
A
P
P
C
I
V
I
S
S
S
A
S
P
T
E
Frog
Xenopus laevis
NP_001080425
785
87931
L497
P
M
L
D
R
A
S
L
V
P
G
S
V
Q
N
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
S588
P
E
A
V
Q
R
S
S
Y
K
D
C
N
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
R610
R
H
G
G
V
Q
M
R
A
Q
P
T
S
R
Q
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
K229
N
I
P
N
L
F
K
K
I
K
G
G
I
Y
T
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
I351
I
D
D
N
L
V
N
I
L
S
S
T
M
G
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.2
99.7
95.1
N.A.
96.6
89.9
N.A.
68.4
30.3
84.3
27.5
N.A.
N.A.
N.A.
38.8
N.A.
Protein Similarity:
100
80.4
99.7
96.2
N.A.
97.7
90.9
N.A.
80.5
48.7
91.7
42.7
N.A.
N.A.
N.A.
49.9
N.A.
P-Site Identity:
100
0
100
100
N.A.
93.3
20
N.A.
6.6
13.3
6.6
13.3
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
13.3
100
100
N.A.
100
40
N.A.
13.3
33.3
26.6
40
N.A.
N.A.
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
26.5
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.1
45.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
8
31
8
8
0
8
39
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
8
0
8
8
% C
% Asp:
0
8
8
8
8
0
0
0
0
0
8
0
0
0
0
% D
% Glu:
0
8
0
0
31
8
8
0
0
0
0
0
0
0
16
% E
% Phe:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
16
24
16
0
0
0
8
31
16
8
0
8
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
8
0
8
8
8
0
0
0
8
31
0
% I
% Lys:
0
8
0
0
0
0
8
8
0
16
8
0
0
0
0
% K
% Leu:
0
0
39
31
16
0
0
8
39
0
0
0
0
0
8
% L
% Met:
0
8
0
0
0
8
16
0
0
0
0
0
8
0
0
% M
% Asn:
16
0
0
16
0
0
8
0
0
8
8
0
8
0
8
% N
% Pro:
16
47
16
8
0
0
0
0
0
8
8
0
8
0
0
% P
% Gln:
0
0
0
0
8
8
0
0
0
8
31
0
0
8
39
% Q
% Arg:
8
0
8
0
8
39
0
16
16
16
0
0
0
8
0
% R
% Ser:
31
0
8
0
0
8
16
47
8
16
8
16
47
8
0
% S
% Thr:
0
0
0
0
0
0
8
8
0
0
8
24
0
16
16
% T
% Val:
8
0
0
8
8
16
0
0
8
0
0
0
16
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
8
0
0
8
8
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _